2023

ARANHA, CECÍLIA M. S. Q. ; REINER, David ; LEITZBACH, Luisa ; LOPES, Flávia Barrio ; Stark, Holger ; FERNANDES, João Paulo dos Santos . Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors. Biooganic & Medicinal Chemistry, v. 78, p. 117132, 2023. LINK

CARMO-MARTINS, Joana I. ; GONZATTI, Michelangelo B. ; VARELA, MARINA T. ; SOUSA, Maria Eduarda P. ; COSTA, LUCAS V. S. ; RODRIGUES, ELAINE GUADELUPE ; FERNANDES, JOÃO PAULO S. ; KELLER, ALEXANDRE C. Esterification of p-Coumaric Acid Improves the Control over Melanoma Cell Growth. Biomedicines, v. 11, p. 196, 2023. LINK

AMARAL, MAIARA ; VARELA, Marina Themoteo ; KANT, Ravi ; CHRISTODOULIDES, Myron ; FERNANDES, João Paulo dos Santos ; TEMPONE, André Gustavo . Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi. Life-Basel, v. 13, p. 663, 2023. LINK

MENGARDA, ANA C. ; SILVA, TAIS C. ; SILVA, ALINE S. ; ROQUINI, DANIEL B. ; FERNANDES, JOÃO PAULO S. ; DE MORAES, Josué . Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments. European Journal of Medicinal Chemistry, v. 251, p. 115268, 2023. LINK

 

2022

VARELA, MARINA T. ; AMARAL, MAIARA ; ROMANELLI, MAIARA M. ; DE CASTRO LEVATTI, ERICA V. ; TEMPONE, ANDRE G. ; FERNANDES, JOÃO PAULO S. . Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi. European Journal of Pharmaceutical Sciences, v. 171, p. 106114, 2022. LINK

WALLER, STEFANIE BRESSAN ; CLEFF, MARLETE BRUM ; RIPOLL, Márcia Kutscher ; MEIRELES, Mário Carlos Araújo ; FERRARINI, Márcio ; VARELA, Marina Themoteo ; FERNANDES, JOÃO PAULO S. . Bioisosteric modification on benzylidene-carbonyl compounds improved the drug-likeness and maintained the antifungal activity against. Chemical Biology & Drug Design, v. 99, p. 391-397, 2022. LINK

OBARA, Ilona ; FERNANDES, João Paulo dos Santos ; TILIGADA, Katerina . Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS). Inflammation Research, v. 71, p. 995-998, 2022. LINK

LOPES, FLÁVIA B. ; ARANHA, CECÍLIA M. S. Q. ; CORRÊA, MICHELLE F. ; FERNANDES, GUSTAVO A. B. ; OKAMOTO, DEBORA N. ; SIMÕES, LEONARDO P. M. ; JUNIOR, NAILTON M. NASCIMENTO ; FERNANDES, JOÃO PAULO S. . Evaluation of the Histamine H3 Receptor Antagonists from LINS01 Series as Cholinesterases Inhibitors - Enzymatic and Modeling Studies. Chemical Biology & Drug Design, v. 100, p. 722-729, 2022. LINK

SANTOS, Laisa Aliandro ; SALLES, Gabriela ; FERNANDES, Gustavo Ariel Borges ; CORREA, Michelle Fidelis ; MARCOURAKIS, Tania ; FERNANDES, João Paulo dos Santos ; GARCIA, Raphael Caio Tamborelli . Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture. Neurotoxicity Research, v. 40, p. 1653-1663, 2022. LINK

FERNANDES, João Paulo dos Santos. Total Parenteral Nutrition and Neuroleptic Malignant-Like Syndrome in Parkinson Disease. American Journal of Therapeutics, v. 29, p. 709-710, 2022. LINK

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2021

LOPES, FB ; ARANHA, CMSQ ; FERNANDES, JPS. Histamine H receptor and cholinesterases as synergistic targets for cognitive decline: strategies to the rational design of multitarget ligands. Chemical Biology & Drug Design, v. 98, p. 212-225, 2021. LINK

FERNANDES, MS ; CASTELO, PM ; CHAVES, GN ; FERNANDES, JPS ; FONSECA, FLA ; ZANATO, LE ; GAVIÃO, MBD . Relationship between polypharmacy, xerostomia, gustatory sensitivity, and swallowing complaints in the elderly: a multidisciplinary approach. Journal of Texture Studies, v. 52, p. 187-196, 2021. LINK

CONSERVA, Geanne A. Alves ; QUIROS-GUERRERO, Luis M. ; COSTA-SILVA, THAIS A. ; MARCOURT, Laurence ; PINTO, Erika Gracielle ; TEMPONE, André Gustavo ; FERNANDES, João Paulo dos Santos ; WOLFENDER, Jean Luc ; QUEIROZ, Emerson F. ; LAGO, João Henrique Ghilardi . Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses. PLoS One, v. 16, p. e0247334, 2021. LINK

CORRÊA, MICHELLE F. ; BALICO-SILVA, ANDRÉ L. ; KISS, DÓRA J. ; FERNANDES, GUSTAVO A.B. ; MARASCHIN, JHONATAN C. ; PARREIRAS-E-SILVA, Lucas T. ; VARELA, MARINA T. ; SIMÕES, SARAH C. ; BOUVIER, MICHEL ; KESER', GYÖRGY M. ; COSTA-NETO, CLAUDIO M. ; FERNANDES, JOÃO PAULO S. . Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors. Bioorganic & Medicinal Chemistry, v. 30, p. 115924, 2021. LINK

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2020

SOLIANI, Andressa ; KUBOTA, Silvia Megumi ; CORRÊA, MICHELLE FIDELIS ; CERUTTI, SUZETE MARIA ; FERNANDES, JOÃO PAULO S. . Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats. Behavioral Brain Research, v. 377, p. 112230, 2020. LINK

VARELA, Marina Themoteo ; FERRARINI, Márcio ; MERCALDI, Vitoria Gallo ; SUFI, Bianca ; PADOVANI, Giovana ; NAZATO, Lucas ; FERNANDES, João Paulo dos Santos . Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches. Bioorganic Chemistry, v. 103, p. 104108, 2020. LINK

OLIVEIRA, LIDIANE ; FERRARINI, Márcio ; DOS SANTOS, ALEXANDRE PAES ; VARELA, Marina Themoteo ; CORRÊA, ISABELA TERESA SANTOS ; TEMPONE, André Gustavo ; MELHEM, MARCIA S.C. ; VALLIM, MARCELO A. ; FERNANDES, JOÃO PAULO S. ; PASCON, RENATA C. . Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity. European Journal of Pharmaceutical Sciences, v. 153, p. 105473, 2020. LINK

WALLER, STEFANIE BRESSAN ; VARELA, Marina Themoteo ; RIPOLL, Márcia Kutscher ; MEIRELES, Mário Carlos Araújo ; CLEFF, MARLETE BRUM ; FERNANDES, João Paulo dos Santos . Benzylidene-carbonyl compounds are active against itraconazole-susceptible and itraconazole-resistant Sporothrix brasiliensis. Folia Microbiologica, v. 65, p. 1033-1038, 2020. LINK

FRANCHIN, TAÍSA BUSARANHO ; ULIAN SILVA, BRUNA CRISTINA ; DEGRANDIS, RONE APARECIDO ; CORRÊA, MICHELLE FIDELIS ; DE QUEIROZ ARANHA, CECÍLIA MARIA SIMÕES ; FERNANDES, JOÃO PAULO S. ; CAMPOS, MICHEL LEANDRO ; PECCININI, Rosângela Gonçalves . Assessment of the physicochemical properties and stability for pharmacokinetic prediction of pyrazinoic acid derivatives. Current Drug Metabolism, v. 21, p. 714-721, 2020. LINK

BALBINO, Aleksandro Martins ; LIMA, Leandro J. S. ; FERNANDES, Gustavo Ariel Borges ; CORREA, Michelle Fidelis ; MELO, Eliane A. G. ; LANDGRAF, Maristella de Almeida Vitta ; FERNANDES, João Paulo dos Santos ; LANDGRAF, Richardt Gama . The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma. Cellular Physiology and Biochemistry, v. 54, p. 1163-1176, 2020. LINK

MORAIS, Thiago Rahal ; CONSERVA, Geanne A. Alves ; VARELA, Marina Themoteo ; COSTA-SILVA, THAIS A. ; THEVENARD, Fernanda ; PONCI, Vitor ; FORTUNA, Ana ; FALCAO, Amílcar Celta ; TEMPONE, André Gustavo ; FERNANDES, João Paulo dos Santos ; LAGO, João Henrique Ghilardi . Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A. Scientific Reports, v. 10, p. 5467, 2020. LINK

VARELA, Marina Themoteo; FERNANDES, João Paulo dos Santos. Natural products: key prototypes to drug discovery against neglected diseases caused by trypanosomatids. Current Medicinal Chemistry, v. 27, p. 2133-2146, 2020. LINK

CORREA, Michelle Fidelis; REINER, David; FERNANDES, Gustavo Ariel Borges; VARELA, Marina Themoteo; ARANHA, Cecília Maria; Stark, Holger; FERNANDES, João Paulo dos Santos. Profiling of LINS01 compounds at human dopamine D2 and D3 receptors. Journal of Chemical Sciences, v. 132, p. 5, 2020. LINK

GINOZA, Milton; FERNANDES, Gustavo Ariel Borges; CORRÊA, Michelle Fidelis; FERNANDES, João Paulo S. Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta. European Journal of Pharmaceutical Sciences, v. 143, p. 105171, 2020. LINK

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2019

VARELA, Marina Themoteo; COSTA-SILVA, Thais A.; LAGO, João Henrique G.; TEMPONE, AndréE G.; FERNANDES, João Paulo dos Santos. Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives. Bioorganic Chemistry, v. 89, p. 102996, 2019. LINK

CORREA, Michelle Fidelis; BARBOSA, Álefe Jhonatas R.; FERNANDES, Gustavo Ariel Borges; BAKER, Jillian G.; FERNANDES, João Paulo dos Santos. Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H1, H2 and H3 receptors. Chemical Biology & Drug Design, v. 93, p. 89-95, 2019. LINK

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2018

FERNANDES, JOÃO PAULO S.. The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist?s Education. American Journal of Pharmaceutical Education, v. 82, p. 6083, 2018. LINK

WALLER, Stefanie; NAKASU, Ceres; SILVA, Anna Luiza; FARIA, Renata de; FERNANDES, João Paulo dos Santos, CLEFF, Marlete Brum. Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation. Brazilian Journal of Pharmaceutical Sciences, v. 54, p. e17858, 2018. LINK

VASCONCELOS, Camila Ioshida; VARELA, Marina Themoteo; TORRECILHAS, Ana Cláudia; FERNANDES, João Paulo dos Santos. Pyrazinoates as Antiparasitic Agents against Trypanosoma cruzi. Archiv der Pharmazie, v. 351, p. 1800190 2018. LINK

CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. QSAR modeling of histamine H3R antagonists/inverse agonists as future drugs for neurodegenerative diseases. Current Neuropharmacology, v. 16, p. 749-757, 2018. LINK

CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. Targeting the Histamine H4 Receptor: Future Drugs for Inflammatory Diseases. Current Organic Chemistry, v. 22, p. 1663-1672, 2018. LINK

VARELA, MARINA T. ; ROMANELI, MAIARA M. ; LIMA, Marta L. ; BORBOREMA, SAMANTA E.T. ; TEMPONE, ANDRE G. ; FERNANDES, JOÃO P.S. . Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods. European Journal of Pharmaceutical Sciences, v. 122, p. 31-41, 2018. LINK

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2017

CORREA, Michelle Fidelis; BARBOSA, Álefe Jhonatas R.; TEIXEIRA, Larissa B.; DUARTE, Diego A.; SIMOES, Sarah C.; PARREIRAS-E-SILVA, Lucas T.; BALBINO, Aleksandro Martins; LANDGRAF, Richardt Gama; BOUVIER, Michel; COSTA NETO, Claudio M.; FERNANDES, João Paulo dos Santos. Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential. Frontiers in Pharmacology, v. 8, p. 825, 2017. LINK

VARELA, Marina Themoteo; LIMA, Marta L.; GALUPPO, Marianna K.; TEMPONE, André Gustavo; OLIVEIRA, Alberto de; LAGO, João Henrique Ghilardi; FERNANDES, João Paulo dos Santos. New alkenyl derivative from Piper mallacophilum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum. Chemical Biology & Drug Design, v. 90, p. 1007-1011, 2017. LINK

Oliveira, Daniela R.; Luchez, Cibele V.; Bortolotto, Zuner A.; Fernandes, João P. S. . Evaluation of β-Aminocarboxylic Acid Derivatives in Hippocampal Excitatory Synaptic Transmission. Archiv der Pharmazie, v. 350, p. 1700179, 2017. LINK

FERNANDES, João Paulo dos Santos. The Importance of the Medicinal Chemistry Knowledge in the Clinical Pharmacist's Education. American Journal of Pharmaceutical Education, v. 82, p. ajpe6083, 2017. LINK

CORREA, Michelle Fidelis; VARELA, Marina Themoteo; BALBINO, Aleksandro Martins; TORRECILHAS, Ana Cláudia; LANDGRAF, Richardt Gama; TRONCONE, Lanfranco Ranieri Paolo; FERNANDES, João Paulo dos Santos. 1-[(2,3-Dihydro-1-benzofuran-2-yl)methyl]piperazines as Novel Anti-inflammatory Compounds: Synthesis and Evaluation on H3R/H4R. Chemical Biology & Drug Design, v. 90, p. 317-322, 2017. LINK

NASCIMENTO, Lillian Ferreira dos Santos; FERNANDES, João Paulo dos Santos. Factorial study to assess an ultrasonic methodology for the allylation of 4-chloroaniline. Green Processing and Synthesis, v. 6, p. 203-210, 2017. LINK

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2016

VARELA, Marina Themoteo; DIAZ, Roberto Zeppellini; MARTINS, Ligia F.; FERREIRA, Daiane D.; TEMPONE, André Gustavo; UENO, Anderson K.; LAGO, João Henrique Ghilardi; FERNANDES, João Paulo dos Santos. Gibbilimbol analogues as antiparasitic agents - synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum. Bioorganic & Medicinal Chemistry Letters, v. 26, p. 1180-1183, 2016. LINK

CORREA, Michelle Fidelis; BARBOSA, Álefe Jhonatas R.; SATO, Rie; JUNQUEIRA, Luis Otavio; POLITI, M.J. ; RANDO, Daniela Gonçales; FERNANDES, João Paulo dos Santos. Factorial design study to access the Green Iodocyclization reaction Of 2-Allylphenols. Green Processing and Synthesis, v. 5, p. 145-151, 2016. LINK

SEGRETTI, Natanael Dante; SIMOES, Cristina Kortstee; CORREA, Michelle Fidelis; FELLI, Veni Maria Andres; MIYATA, Marcelo; CHO, Sang Hyung; FRANZBLAU, Scott Gary; FERNANDES, João Paulo dos Santos. Antimycobacterial activity of pyrazinoate prodrugs in replicating and non-replicating Mycobacterium tuberculosis. Tuberculosis, v. 99, p. 11-16, 2016.  LINK

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2015

CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. Histamine H4 Receptor Ligands: Future Applications And State Of Art. Chemical Biology & Drug Design, v. 85, p. 461-480, 2015. LINK

CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. Pyrazinamide and pyrazinoic acid derivatives directed to mycobacterial enzymes against Tuberculosis. Current Protein and Peptide Science, v. 16, p. 1-1, 2015. LINK

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2013

FERNANDES, João Paulo dos Santos; SAVINO, Giovanna; AMARANTE, André Cortinas Gonçalves; SOUZA, Milena Rodrigues; SILVA, Geane Ramos da; CIANCIULLI, Maria Elisa; CORREA, Michelle Fidelis; FERRARINI, Márcio. Estudo das relações entre estrutura e atividade de parabenos: uma aula prática. Química Nova, v. 36, p. 890-893, 2013. LINK

GADANHA, Aina Narumi; Charline R. Rossini; FERNANDES, João Paulo dos Santos; FERRARINI, Márcio. Stability of carbamide peroxide in gel formulation as prepared in Brazilian compounding pharmacies. Revista Brasileira de Farmácia / Brazilian Journal of Pharmacy, v. 94, p. 115-119, 2013. LINK

FERNANDES, João Paulo dos Santos; PAVAN, Fernando Rogério; LEITE, Clarice Queico Fujimura; FELLI, Veni Maria Andres. Synthesis and evaluation of a pyrazinoic acid prodrug in M. tuberculosis. Saudi Pharmaceutical Journal, v. 22, p. 376-380, 2013. LINK

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2012

FERNANDES, João Paulo dos Santos; MELLO-MOURA, Anna Carolina Volpi; MARQUES, Márcia Martins; NICOLETTI, Maria Aparecida. Cytotoxicity evaluation of Curcuma zedoaria (Christm.) Roscoe fluid extract used in oral hygiene products. Acta Odontologica Scandinavica, v. 70, p. 610-614, 2012. LINK

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2011

FERNANDES, João Paulo dos Santos; PASQUALOTO, Kerly Fernanda Mesquita; FERREIRA, Elizabeth Igne; BRANDT, Carlos Alberto. Molecular modeling and QSAR studies of a set of indole and benzimidazole derivatives as H4 receptor antagonists. Journal of Molecular Modeling, v. 17, p. 921-928, 2011. LINK

FERNANDES, João Paulo dos Santos; CARVALHO, Bruno Simões; LUCHEZ, Cibele Venancio; POLITI, Mário José; BRANDT, Carlos Alberto. Optimization of the ultrasound-assisted synthesis of allyl 1-naphthyl ether using response surface methodology. Ultrasonics Sonochemistry, v. 18, p. 489-493, 2011. LINK

FERREIRA, Amanda Aparecida de Andrade; FERNANDES, João Paulo dos Santos; CASSIARI, Erika de Cássia Prates; FERRARINI, Márcio. Avaliação do efeito da partição de comprimidos de furosemida sobre a uniformidade da dose. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 32, p. 47-53, 2011. LINK

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2010

QUEIROZ, Ariane Cristiane; FERRARINI, Márcio; FERNANDES, João Paulo dos Santos. Interações Medicamentosas Encontradas em Prescrições em uma UBS de Ferraz de Vasconcelos - SP. Acta Farmaceutica Bonaerense, v. 29, p. 298-302, 2010. LINK

GIMENEZ, Bianca Gonçalves; SOUZA, Mariana Santos; FERRARINI, Márcio; FERNANDES, João Paulo dos Santos. Evaluation of blockbuster drugs under the Rule-of-five. Pharmazie, v. 65, p. 148-152, 2010. LINK

FERNANDES, João Paulo dos Santos; PASQUALOTO, Kerly Fernanda Mesquita; FELLI, Veni Maria Andres; FERREIRA, Elizabeth Igne; BRANDT, Carlos Alberto. QSAR Modeling of a Set of Pyrazinoate Esters as Antituberculosis Prodrugs. Archiv der Pharmazie, v. 343, p. 91-97, 2010. LINK

SANTOS, Helen Cristina; RIBEIRO, Roberto Rodrigues; FERRARINI, Márcio; FERNANDES, João Paulo dos Santos. Possíveis interações medicamentosas com psicotrópicos encontradas em pacientes da Zona Leste de São Paulo. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 30, p. 285-289, 2010. LINK

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2009

SILVA, Robson Manoel da; FERNANDES, João Paulo dos Santos. Estudo de utilização de medicamentos por pacientes do jardim elba (SP). Infarma, v. 21, p. 35-38, 2009. LINK

FERNANDES, João Paulo dos Santos; FELLI, Veni Maria Andres. Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design. Química Nova, v. 32, p. 2464-2466, 2009. LINK

PANCOTE, Camila Garcel; CARVALHO, Bruno Simões; LUCHEZ, Cibele Venancio; FERNANDES, João Paulo dos Santos; POLITI, Mário José; BRANDT, Carlos Alberto. Simple and Efficient Access to 3-Ethoxycarbonylpyrroles, Benzofurans, and Naphthofurans. Synthesis, p. 3963-3966, 2009. LINK

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