- Claude Bernard -
“The joy of discovery is certainly more alive than the mind of man can experience.”
Scientific Publications
2023
ARANHA, CECÍLIA M. S. Q. ; REINER, David ; LEITZBACH, Luisa ; LOPES, Flávia Barrio ; Stark, Holger ; FERNANDES, João Paulo dos Santos . Multitargeting approaches to cognitive impairment: Synthesis of aryl-alkylpiperazines and assessment at cholinesterases, histamine H3 and dopamine D3 receptors. Biooganic & Medicinal Chemistry, v. 78, p. 117132, 2023. LINK
CARMO-MARTINS, Joana I. ; GONZATTI, Michelangelo B. ; VARELA, MARINA T. ; SOUSA, Maria Eduarda P. ; COSTA, LUCAS V. S. ; RODRIGUES, ELAINE GUADELUPE ; FERNANDES, JOÃO PAULO S. ; KELLER, ALEXANDRE C. Esterification of p-Coumaric Acid Improves the Control over Melanoma Cell Growth. Biomedicines, v. 11, p. 196, 2023. LINK
AMARAL, MAIARA ; VARELA, Marina Themoteo ; KANT, Ravi ; CHRISTODOULIDES, Myron ; FERNANDES, João Paulo dos Santos ; TEMPONE, André Gustavo . Synthetic Analogues of Gibbilimbol B Induce Bioenergetic Damage and Calcium Imbalance in Trypanosoma cruzi. Life-Basel, v. 13, p. 663, 2023. LINK
MENGARDA, ANA C. ; SILVA, TAIS C. ; SILVA, ALINE S. ; ROQUINI, DANIEL B. ; FERNANDES, JOÃO PAULO S. ; DE MORAES, Josué . Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments. European Journal of Medicinal Chemistry, v. 251, p. 115268, 2023. LINK
2022
VARELA, MARINA T. ; AMARAL, MAIARA ; ROMANELLI, MAIARA M. ; DE CASTRO LEVATTI, ERICA V. ; TEMPONE, ANDRE G. ; FERNANDES, JOÃO PAULO S. . Optimization of physicochemical properties is a strategy to improve drug-likeness associated with activity: Novel active and selective compounds against Trypanosoma cruzi. European Journal of Pharmaceutical Sciences, v. 171, p. 106114, 2022. LINK
WALLER, STEFANIE BRESSAN ; CLEFF, MARLETE BRUM ; RIPOLL, Márcia Kutscher ; MEIRELES, Mário Carlos Araújo ; FERRARINI, Márcio ; VARELA, Marina Themoteo ; FERNANDES, JOÃO PAULO S. . Bioisosteric modification on benzylidene-carbonyl compounds improved the drug-likeness and maintained the antifungal activity against. Chemical Biology & Drug Design, v. 99, p. 391-397, 2022. LINK
OBARA, Ilona ; FERNANDES, João Paulo dos Santos ; TILIGADA, Katerina . Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS). Inflammation Research, v. 71, p. 995-998, 2022. LINK
LOPES, FLÁVIA B. ; ARANHA, CECÍLIA M. S. Q. ; CORRÊA, MICHELLE F. ; FERNANDES, GUSTAVO A. B. ; OKAMOTO, DEBORA N. ; SIMÕES, LEONARDO P. M. ; JUNIOR, NAILTON M. NASCIMENTO ; FERNANDES, JOÃO PAULO S. . Evaluation of the Histamine H3 Receptor Antagonists from LINS01 Series as Cholinesterases Inhibitors - Enzymatic and Modeling Studies. Chemical Biology & Drug Design, v. 100, p. 722-729, 2022. LINK
SANTOS, Laisa Aliandro ; SALLES, Gabriela ; FERNANDES, Gustavo Ariel Borges ; CORREA, Michelle Fidelis ; MARCOURAKIS, Tania ; FERNANDES, João Paulo dos Santos ; GARCIA, Raphael Caio Tamborelli . Neurotoxicity Assessment of 1-[(2,3-Dihydro-1-Benzofuran-2-yl)Methyl]Piperazine (LINS01 Series) Derivatives and their Protective Effect on Cocaine-Induced Neurotoxicity Model in SH-SY5Y Cell Culture. Neurotoxicity Research, v. 40, p. 1653-1663, 2022. LINK
FERNANDES, João Paulo dos Santos. Total Parenteral Nutrition and Neuroleptic Malignant-Like Syndrome in Parkinson Disease. American Journal of Therapeutics, v. 29, p. 709-710, 2022. LINK
2021
LOPES, FB ; ARANHA, CMSQ ; FERNANDES, JPS. Histamine H receptor and cholinesterases as synergistic targets for cognitive decline: strategies to the rational design of multitarget ligands. Chemical Biology & Drug Design, v. 98, p. 212-225, 2021. LINK
FERNANDES, MS ; CASTELO, PM ; CHAVES, GN ; FERNANDES, JPS ; FONSECA, FLA ; ZANATO, LE ; GAVIÃO, MBD . Relationship between polypharmacy, xerostomia, gustatory sensitivity, and swallowing complaints in the elderly: a multidisciplinary approach. Journal of Texture Studies, v. 52, p. 187-196, 2021. LINK
CONSERVA, Geanne A. Alves ; QUIROS-GUERRERO, Luis M. ; COSTA-SILVA, THAIS A. ; MARCOURT, Laurence ; PINTO, Erika Gracielle ; TEMPONE, André Gustavo ; FERNANDES, João Paulo dos Santos ; WOLFENDER, Jean Luc ; QUEIROZ, Emerson F. ; LAGO, João Henrique Ghilardi . Metabolite profile of Nectandra oppositifolia Nees & Mart. and assessment of antitrypanosomal activity of bioactive compounds through efficiency analyses. PLoS One, v. 16, p. e0247334, 2021. LINK
CORRÊA, MICHELLE F. ; BALICO-SILVA, ANDRÉ L. ; KISS, DÓRA J. ; FERNANDES, GUSTAVO A.B. ; MARASCHIN, JHONATAN C. ; PARREIRAS-E-SILVA, Lucas T. ; VARELA, MARINA T. ; SIMÕES, SARAH C. ; BOUVIER, MICHEL ; KESER', GYÖRGY M. ; COSTA-NETO, CLAUDIO M. ; FERNANDES, JOÃO PAULO S. . Novel potent (dihydro)benzofuranyl piperazines as human histamine receptor ligands - Functional characterization and modeling studies on H3 and H4 receptors. Bioorganic & Medicinal Chemistry, v. 30, p. 115924, 2021. LINK
2020
SOLIANI, Andressa ; KUBOTA, Silvia Megumi ; CORRÊA, MICHELLE FIDELIS ; CERUTTI, SUZETE MARIA ; FERNANDES, JOÃO PAULO S. . Differential contribution of H3R antagonism by LINS01 compounds on memory, anxiety-like behaviour and spontaneous locomotor activity in healthy rats. Behavioral Brain Research, v. 377, p. 112230, 2020. LINK
VARELA, Marina Themoteo ; FERRARINI, Márcio ; MERCALDI, Vitoria Gallo ; SUFI, Bianca ; PADOVANI, Giovana ; NAZATO, Lucas ; FERNANDES, João Paulo dos Santos . Coumaric acid derivatives as tyrosinase inhibitors: Efficacy studies through in silico, in vitro and ex vivo approaches. Bioorganic Chemistry, v. 103, p. 104108, 2020. LINK
OLIVEIRA, LIDIANE ; FERRARINI, Márcio ; DOS SANTOS, ALEXANDRE PAES ; VARELA, Marina Themoteo ; CORRÊA, ISABELA TERESA SANTOS ; TEMPONE, André Gustavo ; MELHEM, MARCIA S.C. ; VALLIM, MARCELO A. ; FERNANDES, JOÃO PAULO S. ; PASCON, RENATA C. . Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity. European Journal of Pharmaceutical Sciences, v. 153, p. 105473, 2020. LINK
WALLER, STEFANIE BRESSAN ; VARELA, Marina Themoteo ; RIPOLL, Márcia Kutscher ; MEIRELES, Mário Carlos Araújo ; CLEFF, MARLETE BRUM ; FERNANDES, João Paulo dos Santos . Benzylidene-carbonyl compounds are active against itraconazole-susceptible and itraconazole-resistant Sporothrix brasiliensis. Folia Microbiologica, v. 65, p. 1033-1038, 2020. LINK
FRANCHIN, TAÍSA BUSARANHO ; ULIAN SILVA, BRUNA CRISTINA ; DEGRANDIS, RONE APARECIDO ; CORRÊA, MICHELLE FIDELIS ; DE QUEIROZ ARANHA, CECÍLIA MARIA SIMÕES ; FERNANDES, JOÃO PAULO S. ; CAMPOS, MICHEL LEANDRO ; PECCININI, Rosângela Gonçalves . Assessment of the physicochemical properties and stability for pharmacokinetic prediction of pyrazinoic acid derivatives. Current Drug Metabolism, v. 21, p. 714-721, 2020. LINK
BALBINO, Aleksandro Martins ; LIMA, Leandro J. S. ; FERNANDES, Gustavo Ariel Borges ; CORREA, Michelle Fidelis ; MELO, Eliane A. G. ; LANDGRAF, Maristella de Almeida Vitta ; FERNANDES, João Paulo dos Santos ; LANDGRAF, Richardt Gama . The Novel H4R Antagonist 1-[(5-Chloro-2,3-Dihydro-1-Benzofuran-2-Yl)Methyl]-4-Methyl-Piperazine (LINS01007) Attenuates Several Symptoms in Murine Allergic Asthma. Cellular Physiology and Biochemistry, v. 54, p. 1163-1176, 2020. LINK
MORAIS, Thiago Rahal ; CONSERVA, Geanne A. Alves ; VARELA, Marina Themoteo ; COSTA-SILVA, THAIS A. ; THEVENARD, Fernanda ; PONCI, Vitor ; FORTUNA, Ana ; FALCAO, Amílcar Celta ; TEMPONE, André Gustavo ; FERNANDES, João Paulo dos Santos ; LAGO, João Henrique Ghilardi . Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A. Scientific Reports, v. 10, p. 5467, 2020. LINK
VARELA, Marina Themoteo; FERNANDES, João Paulo dos Santos. Natural products: key prototypes to drug discovery against neglected diseases caused by trypanosomatids. Current Medicinal Chemistry, v. 27, p. 2133-2146, 2020. LINK
CORREA, Michelle Fidelis; REINER, David; FERNANDES, Gustavo Ariel Borges; VARELA, Marina Themoteo; ARANHA, Cecília Maria; Stark, Holger; FERNANDES, João Paulo dos Santos. Profiling of LINS01 compounds at human dopamine D2 and D3 receptors. Journal of Chemical Sciences, v. 132, p. 5, 2020. LINK
GINOZA, Milton; FERNANDES, Gustavo Ariel Borges; CORRÊA, Michelle Fidelis; FERNANDES, João Paulo S. Novel potent vasodilating agents: Evaluation of the activity and potency of LINS01005 and derivatives in rat aorta. European Journal of Pharmaceutical Sciences, v. 143, p. 105171, 2020. LINK
2019
VARELA, Marina Themoteo; COSTA-SILVA, Thais A.; LAGO, João Henrique G.; TEMPONE, AndréE G.; FERNANDES, João Paulo dos Santos. Evaluation of the antitrypanosoma activity and SAR study of novel LINS03 derivatives. Bioorganic Chemistry, v. 89, p. 102996, 2019. LINK
CORREA, Michelle Fidelis; BARBOSA, Álefe Jhonatas R.; FERNANDES, Gustavo Ariel Borges; BAKER, Jillian G.; FERNANDES, João Paulo dos Santos. Pharmacological and SAR analysis of the LINS01 compounds at the human histamine H1, H2 and H3 receptors. Chemical Biology & Drug Design, v. 93, p. 89-95, 2019. LINK
2018
FERNANDES, JOÃO PAULO S.. The Importance of Medicinal Chemistry Knowledge in the Clinical Pharmacist?s Education. American Journal of Pharmaceutical Education, v. 82, p. 6083, 2018. LINK
WALLER, Stefanie; NAKASU, Ceres; SILVA, Anna Luiza; FARIA, Renata de; FERNANDES, João Paulo dos Santos, CLEFF, Marlete Brum. Anti-Sporothrix brasiliensis activity of different pyrazinoic acid prodrugs: a repurposing evaluation. Brazilian Journal of Pharmaceutical Sciences, v. 54, p. e17858, 2018. LINK
VASCONCELOS, Camila Ioshida; VARELA, Marina Themoteo; TORRECILHAS, Ana Cláudia; FERNANDES, João Paulo dos Santos. Pyrazinoates as Antiparasitic Agents against Trypanosoma cruzi. Archiv der Pharmazie, v. 351, p. 1800190 2018. LINK
CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. QSAR modeling of histamine H3R antagonists/inverse agonists as future drugs for neurodegenerative diseases. Current Neuropharmacology, v. 16, p. 749-757, 2018. LINK
CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. Targeting the Histamine H4 Receptor: Future Drugs for Inflammatory Diseases. Current Organic Chemistry, v. 22, p. 1663-1672, 2018. LINK
VARELA, MARINA T. ; ROMANELI, MAIARA M. ; LIMA, Marta L. ; BORBOREMA, SAMANTA E.T. ; TEMPONE, ANDRE G. ; FERNANDES, JOÃO P.S. . Antiparasitic activity of new gibbilimbol analogues and SAR analysis through efficiency and statistical methods. European Journal of Pharmaceutical Sciences, v. 122, p. 31-41, 2018. LINK
2017
CORREA, Michelle Fidelis; BARBOSA, Álefe Jhonatas R.; TEIXEIRA, Larissa B.; DUARTE, Diego A.; SIMOES, Sarah C.; PARREIRAS-E-SILVA, Lucas T.; BALBINO, Aleksandro Martins; LANDGRAF, Richardt Gama; BOUVIER, Michel; COSTA NETO, Claudio M.; FERNANDES, João Paulo dos Santos. Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential. Frontiers in Pharmacology, v. 8, p. 825, 2017. LINK
VARELA, Marina Themoteo; LIMA, Marta L.; GALUPPO, Marianna K.; TEMPONE, André Gustavo; OLIVEIRA, Alberto de; LAGO, João Henrique Ghilardi; FERNANDES, João Paulo dos Santos. New alkenyl derivative from Piper mallacophilum and analogues: Antiparasitic activity against Trypanosoma cruzi and Leishmania infantum. Chemical Biology & Drug Design, v. 90, p. 1007-1011, 2017. LINK
Oliveira, Daniela R.; Luchez, Cibele V.; Bortolotto, Zuner A.; Fernandes, João P. S. . Evaluation of β-Aminocarboxylic Acid Derivatives in Hippocampal Excitatory Synaptic Transmission. Archiv der Pharmazie, v. 350, p. 1700179, 2017. LINK
CORREA, Michelle Fidelis; VARELA, Marina Themoteo; BALBINO, Aleksandro Martins; TORRECILHAS, Ana Cláudia; LANDGRAF, Richardt Gama; TRONCONE, Lanfranco Ranieri Paolo; FERNANDES, João Paulo dos Santos. 1-[(2,3-Dihydro-1-benzofuran-2-yl) methyl]piperazines as Novel Anti-inflammatory Compounds: Synthesis and Evaluation on H3R/H4R. Chemical Biology & Drug Design, v. 90, p. 317-322, 2017. LINK
NASCIMENTO, Lillian Ferreira dos Santos; FERNANDES, João Paulo dos Santos. Factorial study to assess an ultrasonic methodology for the allylation of 4-chloroaniline. Green Processing and Synthesisv. 6, p. 203-210, 2017. LINK
VARELA, Marina Themoteo; DIAZ, Roberto Zeppellini; MARTINS, Ligia F.; FERREIRA, Daiane D.; TEMPONE, André Gustavo; UENO, Anderson K.; LAGO, João Henrique Ghilardi; FERNANDES, João Paulo dos Santos. Gibbilimbol analogues as antiparasitic agents - synthesis and biological activity against Trypanosoma cruzi and Leishmania (L.) infantum. Bioorganic & Medicinal Chemistry Letters, v. 26, p. 1180-1183, 2016. LINK
CORREA, Michelle Fidelis; BARBOSA, Álefe Jhonatas R.; SATO, Rie; JUNQUEIRA, Luis Otavio; POLITI, M.J. ; RANDO, Daniela Gonçales; FERNANDES, João Paulo dos Santos. Factorial design study to access the Green Iodocyclization reaction Of 2-Allylphenols. Green Processing and Synthesis, v. 5, p. 145-151, 2016. LINK
SEGRETTI, Natanael Dante; SIMOES, Cristina Kortstee; CORREA, Michelle Fidelis; FELLI, Veni Maria Andres; MIYATA, Marcelo; CHO, Sang Hyung; FRANZBLAU, Scott Gary; FERNANDES, João Paulo dos Santos. Antimycobacterial activity of pyrazinoate prodrugs in replicating and non-replicating Mycobacterium tuberculosis. Tuberculosis, v. 99, p. 11-16, 2016. LINK
2015
CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. Histamine H4 Receptor Ligands: Future Applications And State Of Art. Chemical Biology & Drug Design, v. 85, p. 461-480, 2015. LINK
CORREA, Michelle Fidelis; FERNANDES, João Paulo dos Santos. Pyrazinamide and pyrazinoic acid derivatives directed to mycobacterial enzymes against Tuberculosis. Current Protein and Peptide Science, v. 16, p. 1-1, 2015. LINK
2013
FERNANDES, João Paulo dos Santos; SAVINO, Giovanna; AMARANTE, André Cortinas Gonçalves; SOUZA, Milena Rodrigues; SILVA, Geane Ramos da; CIANCIULLI, Maria Elisa; CORREA, Michelle Fidelis; FERRARINI, Márcio. Estudo das relações entre estrutura e atividade de parabenos: uma aula prática. Química Nova, v. 36, p. 890-893, 2013. LINK
GADANHA, Aina Narumi; Charline R. Rossini; FERNANDES, João Paulo dos Santos; FERRARINI, Márcio. Stability of carbamide peroxide in gel formulation as prepared in Brazilian compounding pharmacies. Revista Brasileira de Farmácia / Brazilian Journal of Pharmacy, v. 94, p. 115-119, 2013. LINK
FERNANDES, João Paulo dos Santos; PAVAN, Fernando Rogério; LEITE, Clarice Queico Fujimura; FELLI, Veni Maria Andres. Synthesis and evaluation of a pyrazinoic acid prodrug in M. tuberculosis. Saudi Pharmaceutical Journal, v. 22, p. 376-380, 2013. LINK
2012
FERNANDES, João Paulo dos Santos; MELLO-MOURA, Anna Carolina Volpi; MARQUES, Márcia Martins; NICOLETTI, Maria Aparecida. Cytotoxicity evaluation of Curcuma zedoaria (Christm.) Roscoe fluid extract used in oral hygiene products. Acta Odontologica Scandinavica, v. 70, p. 610-614, 2012. LINK
2011
FERNANDES, João Paulo dos Santos; PASQUALOTO, Kerly Fernanda Mesquita; FERREIRA, Elizabeth Igne; BRANDT, Carlos Alberto. Molecular modeling and QSAR studies of a set of indole and benzimidazole derivatives as H4 receptor antagonists. Journal of Molecular Modeling, v. 17, p. 921-928, 2011. LINK
FERNANDES, João Paulo dos Santos; CARVALHO, Bruno Simões; LUCHEZ, Cibele Venancio; POLITI, Mário José; BRANDT, Carlos Alberto. Optimization of the ultrasound-assisted synthesis of allyl 1-naphthyl ether using response surface methodology. Ultrasonics Sonochemistry, v. 18, p. 489-493, 2011. LINK
FERREIRA, Amanda Aparecida de Andrade; FERNANDES, João Paulo dos Santos; CASSIARI, Erika de Cássia Prates; FERRARINI, Márcio. Avaliação do efeito da partição de comprimidos de furosemida sobre a uniformidade da dose. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 32, p. 47-53, 2011. LINK
2010
QUEIROZ, Ariane Cristiane; FERRARINI, Márcio; FERNANDES, João Paulo dos Santos. Interações Medicamentosas Encontradas em Prescrições em uma UBS de Ferraz de Vasconcelos - SP. Acta Farmaceutica Bonaerense, v. 29, p. 298-302, 2010. LINK
GIMENEZ, Bianca Gonçalves; SOUZA, Mariana Santos; FERRARINI, Márcio; FERNANDES, João Paulo dos Santos. Evaluation of blockbuster drugs under the Rule-of-five. Pharmazie, v. 65, p. 148-152, 2010. LINK
FERNANDES, João Paulo dos Santos; PASQUALOTO, Kerly Fernanda Mesquita; FELLI, Veni Maria Andres; FERREIRA, Elizabeth Igne; BRANDT, Carlos Alberto. QSAR Modeling of a Set of Pyrazinoate Esters as Antituberculosis Prodrugs. Archiv der Pharmazie, v. 343, p. 91-97, 2010. LINK
SANTOS, Helen Cristina; RIBEIRO, Roberto Rodrigues; FERRARINI, Márcio; FERNANDES, João Paulo dos Santos. Possíveis interações medicamentosas com psicotrópicos encontradas em pacientes da Zona Leste de São Paulo. Revista de Ciências Farmacêuticas Básica e Aplicada, v. 30, p. 285-289, 2010. LINK
2009
SILVA, Robson Manoel da; FERNANDES, João Paulo dos Santos. Estudo de utilização de medicamentos por pacientes do jardim elba (SP). Infarma, v. 21, p. 35-38, 2009. LINK
FERNANDES, João Paulo dos Santos; FELLI, Veni Maria Andres. Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design. Química Nova, v. 32, p. 2464-2466, 2009. LINK
PANCOTE, Camila Garcel; CARVALHO, Bruno Simões; LUCHEZ, Cibele Venancio; FERNANDES, João Paulo dos Santos; POLITI, Mário José; BRANDT, Carlos Alberto. Simple and Efficient Access to 3-Ethoxycarbonylpyrroles, Benzofurans, and Naphthofurans. Synthesis, p. 3963-3966, 2009. LINK